Viskazide 1025 HCTZ 3×35 Tabs




3×35 Tablets




One or two VISKAZIDE® tablets once daily in the morning can be used to administer up to 20 mg pindolol and 100 mg hydrochlorothiazide

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What the medication is used for:

Viskazide can be used as maintenance therapy for individuals with hypertension who require a combination of pindolol and hydrochlorothiazide in the dosages present in Viskazide.

What it does:

Viskazide works to increase urine production to reduce sodium content and reduce the heart rate. Both of these actions help reduce blood pressure

When it should not be used:

Viskazide should not be used in the presence of:

  • Congestive heart failure
  • Right ventricular failure secondary to pulmonary hypertension
  • Significant cardiomegaly
  • Sinus bradycardia (< 45 -50 beats/min)
  • Second and third degree A-V block
  • Cardiogenic shock
  • Bronchospasm (including bronchial asthma), or severe chronic obstructive pulmonary disease
  • Anesthesia with agents that produce myocardial depression, e.g., ether
  • Anuria
  • Hypersensitivity to pindolol, hydrochlorothiazide, or to sulfonamide-derived drugs, or crosssensitivity to other beta blockers
  • Prinzmetal’s angina (variant angina)
  • Sick sinus syndrome
  • Severe peripheral arterial circulatory disturbances
  • Untreated pheochromocytoma

What the medicinal ingredient is:

10 mg of pindolol, a beta-adrenergic receptor-blocking agent, and 25 or 50 mg of hydrochlorothiazide, a diuretic, per tablet

What the nonmedicinal ingredients are:

Cellulose microcrystalline, magnesium stearate, pregelatinized starch, silica colloidal anhydrous

What dosage forms it comes in:

Tablets; 10/25 and 10/50 mg



Hypertension, or high blood pressure in the arteries, is diagnosed when the force of blood flowing through an individual’s blood vessels is consistently too high. This can be caused by several factors and is very common, especially over the age of 60.

Hypertension treatment is typically done through medication and nutritional alterations. Some medications include:

  • Diuretics: increases urination which reduces the sodium and fluid content resulting in decreased blood pressure.
  • Beta blockers: helps reduce the heart rate, decreasing blood pressure.
  • Alpha blockers: relaxes the muscles of arteries and veins.

Patient-dependent dietary changes may be made as well, including avoiding frozen, salty, and sugary foods; caffeine and alcohol; and red meats.



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How does this medication work? What will it do for me?
Viskazide is a combination medication of pindolol and hydrochlorothiazide used as maintenance therapy for hypertension
What form(s) does this medication come in?

Capsule (20 mg)

Each delayed-release capsule with an opaque pink body, opaque reddish-brown cap, printed in black with “20” on the body and “A O M” on the cap, contains 20 mg of omeprazole. Nonmedicinal ingredients: disodium hydrogen phosphate dihydrate, gelatin, hydroxypropyl cellulose, hydroxypropyl methylcellulose, iron oxide, lactose anhydrous, magnesium stearate, mannitol, methacrylic acid copolymer, microcrystalline cellulose, polyethylene glycol, sodium lauryl sulfate, and titanium dioxide.

Tablet (20 mg)
Each red-brown, round, delayed-release tablet printed “LOSEC 20” on both sides contains 20 mg of omeprazole. Nonmedicinal ingredients: hydroxypropyl methylcellulose, iron oxide, mannitol, methacrylic acid copolymer, microcrystalline cellulose, paraffin, polyethylene glycol, sodium starch glycolate, sodium stearyl fumarate, talc, and titanium dioxide

What is the difference between the capsule and the tablet

The omeprazole capsule (as a multiple unit formulation) is usually emptied gradually from the stomach into the intestine. In contrast to the capsule, the tablet (as a single unit formulation) will enter the intestine and dissolve as one unit. Consequently, the absorption and first pass metabolism of the tablet take place only during a very limited period.

LOSEC tablets are absorbed rapidly

How should I use this medication?

The usual recommended dose of LOSEC is 10 mg to 40 mg once daily. The dose and length of treatment depend on the condition being treated. This medication can be taken with or without food and should be swallowed whole with water.

When used to treat ulcers in the duodenum, the recommended adult dose is 20 mg taken once daily for 2 to 4 weeks.

To treat ulcers in the stomach, reflux esophagitis, and ulcers associated with the use of NSAIDs, the recommended adult dose is 20 mg taken once daily for 4 to 8 weeks.

For the treatment of heartburn, the recommended adult dose is 20 mg daily.

When used to treat stomach ulcers caused by H. pylori in adults, the dose of LOSEC is 20 mg taken 2 times daily with 1,000 mg of amoxicillin 2 times daily and 500 mg of clarithromycin 2 times daily, all for 7 days. Another dosing regimen for H. pylori infections is 20 mg of LOSEC, 500 mg of metronidazole, and 250 mg of clarithromycin, all twice daily for 7 days.

If your ulcer continues to bother you, your doctor may suggest that you continue taking LOSEC for a period of time to make sure that your ulcer is fully healed.

When treating Zollinger-Ellison syndrome, the dose of LOSEC varies but is often higher than the doses used to treat ulcers. Doses larger than 80 mg daily are often needed.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is less than 12 hours until your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not use this medication if you:

  • Have heartburn symptoms
  • Are allergic to LOSEC or any ingredients of this medication
  • Allergic to Rilpivirine
What side effects are possible with this medication?

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

    • abdominal or stomach pain
    • constipation
    • diarrhea or loose stools
    • dizziness
    • dry mouth
    • gas
    • headache
    • muscle weakness
    • nausea
    • sensation of spinning
    • sleepiness
    • trouble sleeping
    • vomiting

Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

    • blurred vision
    • diarrhea (watery and severe; may also be bloody)
    • increased sensitivity to sunlight
    • joint pain
    • mild skin rash or itching
    • mouth inflammation
    • muscle aches or cramps
    • pain or burning in the mouth or throat
    • rash on cheeks or arms that gets worse in the sun
    • the sensation of burning, prickling, or numbness
    • signs of kidney problems (e.g., blood in the urine, decreased urine production)
    • signs of liver damage (yellow skin or eyes, dark urine, loss of appetite, abdominal pain, fever, and fatigue)

Stop taking the medication and seek immediate medical attention if any of the following occur:

    • signs of an allergic reaction (e.g., difficulty breathing, hives, swelling of the face or throat)
    • signs of bleeding in the stomach (e.g., bloody, black, or tarry stools; spitting up of blood; vomiting blood or material that looks like coffee grounds)
    • signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication

Diarrhea: When gastric acid is decreased, the number of bacteria normally in the digestive system increases. Occasionally, this can cause serious infection in the digestive tract. If you experience watery, foul-smelling bowel movements after starting to take Losec, contact your doctor as soon as possible.

Fluid and electrolyte balance: Losec, like other PPIs, may cause the levels of electrolytes such as potassium, sodium, magnesium, chloride, and calcium in the blood to change while taking this medication. If you experience symptoms of fluid and electrolyte imbalance such as muscle pains or cramps; dry mouth; numb hands, feet, or lips; or racing heartbeat, contact your doctor as soon as possible. Your doctor will do blood tests regularly to monitor the levels of these electrolytes in your blood while you are taking this medication.

Liver function: Liver disease or reduced liver function may cause this medication to build up in the body. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication. People with severe liver disease should generally not take more than 20 mg of Losec daily.

Methotrexate interaction: Losec, like other medications in this group, may interact with methotrexate when the two medications are used at the same time. This combination may lead to higher than expected amounts of methotrexate in the body and can cause serious side effects, including kidney damage, irregular heartbeat, anemia, or infection. If you take Losec are also going to receive a dose of methotrexate, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Osteoporosis-related fractures: Studies suggest that the use of Losec, like other PPIs, may be related to an increased risk of fractures, particularly for people who take this medication for a year or longer. The lowest dose of this medication to control the symptoms, taken for the shortest period of time is less likely to cause these problems.

Severe stomach problems: If you have recurrent vomiting, difficulty swallowing, blood in the stool, coughing up of blood, or significant unintentional weight loss, check with your doctor immediately. These symptoms may be signs of a more serious stomach problem.

Subacute cutaneous lupus erythematosus (SCLE): Losec, like other PPIs, has been rarely associated with SCLE, an autoimmune disease.  If you develop any skin lesions, especially in sun-exposed skin areas, and if accompanied by muscle aches or pains, contact your doctor immediately.

Vitamin B12: Long-term use of Losec may lead to vitamin B12 deficiency. If you are a vegetarian or have low vitamin B12 levels, discuss with your doctor whether any special monitoring is required.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, call your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking Losec, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

What other drugs could interact with this medication?

There may be an interaction between LOSEC and any of the following:

    • amphetamines (e.g., dextroamphetamine, lisdexamfetamine)
    • apalutamide
    • “azole” antifungals (e.g., itraconazole, ketoconazole, voriconazole)
    • bisphosphonates (e.g., alendronate, etidronate, risedronate)
    • bosentan
    • cannabis
    • capecitabine
    • cefuroxime
    • clobazam
    • clopidogrel
    • clozapine
    • cyclosporine
    • dabigatran
    • dexmethylphenidate
    • digoxin
    • doxycycline
    • elagolix
    • enzalutamide
    • hepatitis C antivirals (e.g., dasabuvir, ledipasvir, ombitasvir, paritaprevir, ritonavir, velpatasvir)
    • HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
    • iron salts (e.g., ferrous fumarate, ferrous sulfate)
    • lumacaftor
    • mesalamine
    • methotrexate
    • methylphenidate
    • multivitamins with iron, folate
    • mycophenolate
    • pazopanib
    • phenytoin
    • protein kinase inhibitors (e.g., bosutinib, dasatinib, nilotinib, pazopanib)
    • raltegravir
    • rifampin
    • rilpivirine
    • riociguat
    • St. John’s wort
    • SSRI antidepressants (e.g., citalopram, escitalopram, fluoxetine, fluvoxamine)
    • tacrolimus
    • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

    • stop taking one of the medications,
    • change one of the medications to another,
    • change how you are taking one or both of the medications, or
    • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also, tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them

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