REVIVAL PRP® for Hair Restoration






11ml and 22ml Tubes


Indicated for the acceleration of bone and tissue healing


Intended for use only by physicians. Please refer to instruction sheet

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REVIVAL PRP® is an Advanced Separator Gel-based, easy to use, sterile system that is used to prepare PRP in a safe and effective manner to accelerate the body’s own natural healing process.

PRP is used in various medical applications including tissue enhancement, treatment of tissue and cell regeneration, rejuvenation, reconstruction and for general healing and repair in various fields of medicine. PRP is indicated for the acceleration of bone and tissue healing in the following areas:

  • Chronic Wounds
  • Orthopedics
  • Veterinary
  • General Surgery
  • Post operation wounds
  • Sports Medicine
  • Biological Glue
  • Esthetics & Cosmetic surgery
  • Urology
  • Dermatology
  • Scalp cure & hair treatment
  • Dental & Periodontal
  • Ophthalmology


Hair loss is a condition that affects many people at some points in their lives. Normally most people lose about 50- 100 strands of hair a day, however hair loss usually refers to an excessive amount of hair being lost from the scalp or on another part of the body.

Alopecia refers to hair loss on the body or the scalp. Alopecia occurs in both men and women, though hair loss occurs slightly more in men than in women.

  • Involutional alopecia is a natural condition that occurs with age that results in the thinning of the hair.
  • Androgenic alopecia is common form a hair loss. In men it is known as male pattern baldness. Hair loss recedes over the temple of the scalp and the crown of the head and can progress to partial or complete baldness. In women this condition is known as female pattern baldness. This results in the thinning of the hair all over the scalp but rarely does the hairline recede nor result in total baldness.
  • Alopecia areata is a form of hair loss that causes the hair to fall out in small patches or spots.
  • Alopecia totalis is the loss of all scalp and facial hair.
  • Alopecia universalis is a condition that causes all hair on the scalp and body to fall out.
  • Cicatricial (scarring) alopecia is permanent hair loss caused by scarring and other skin disorders that destroy the ability of the hair to regenerate.
  • Traction alopecia is caused primarily by a pulling force being applied to the hair. This commonly results from the individual frequently wearing their hair in a particularly tight ponytail, or braids.

Signs and symptoms of hair loss may include:

  • Thinning of hair on the top of the head or clumps of hair falling out
  • Nail problems, such as white spots or lines appearing on nails
  • Sudden loosening of the hair and patchy hair loss.

Medical attention should be sought if hair loss is sudden and is falling out in patches as it may be an underlying cause of a medical condition.


Medications are a common option used to help restore hair growth. For instance, Minoxidil is a drug therapy that is used topically to help regrow the sections of the scalp that have gone bald. Finasteride is taken orally to block the formation of male hormones in the skin that cause hair loss.


Used mostly as a treatment for permanent hair loss.
Sections of the scalp that are bald are removed and hair follicles are implanted in these areas to stimulate hair regrowth.


These lasers are used to help stimulate hair follicles to improve hair density.


Lifestyle changes and home remedies are alternative treatments for alopecia as well.
Changing your diet, such as by adding more protein and iron may help improve overall hair quality.
Trying to manage stress is another way to reduce hair loss.
Additionally, styling techniques such as wigs, scarves and hair pieces might be beneficial to help cover permanent or temporary hair loss.

Platelet-rich plasma (PRP) carries various growth factors that stimulate cell proliferation and differentiation. Growth factors found in platelet-rich plasma affect the signaling involved in hair follicle development and cycling.

PRP therapy represents a new and effective treatment option with minimal associated side effects for those who suffer from alopecia. Blood is drawn from the patient then placed in a centrifuge to separate the red blood cells and the platelet-rich plasma. The injections are generally administered intradermally or subcutaneously in the patients desired sites on the scalp. When PRP is administered, the growth factors in the platelets’ granules bind to the bulge area of the hair follicle leading to the formation of hair epithelium and the differentiation of stem cells in the hair follicles. This stimulates the hair follicles allowing new hair strands to grow.

PRP injections for hair loss treatment offers promising therapeutic effects. PRP injections are autologous therefore there are little to no adverse side effects associated with the treatment.  Due to its regenerative effects and action mechanisms, PRP offers a potential long-term treatment for hair regrowth compared to other conventional medical treatments or therapies.


Platelet Rich Plasma (PRP) is a portion of your own blood plasma that is concentrated in platelets and growth factors. These are critical in triggering the body’s regenerative mechanisms.


The most basic method to prepare PRP is through centrifugation. The blood is drawn and centrifuged at a specific speed until it is separated into 3 layers: Platelet Poor Plasma (PPP), Buffy Coat/Platelet Rich Plasma (PRP) and red blood cells.

REVIVAL PRP’s Advanced Separator Gel sits in between the platelet-rich plasma and the red blood cells to ensure that the physician obtains a plasma preparation that is free from any red blood cells. Red blood cell contamination may provoke an inflammatory effect which can affect healing.

Depending on the application, calcium chloride is added to form a fibrin clot, which this then applied to the affected area


The platelets undergo degranulation to release Growth Factors (GFs) with healing properties. The plasma contains cytokines, thrombin, and other GFs with inherent biological and adhesive properties.

Growth Factors Present in Platelets and their Function

Transforming Growth Factor-beta

  • Stimulates undifferentiated mesenchymal cell proliferations
  • Regulates endothelial, fibroblastic and osteoblastic mitogenesis
  • Regulates collagen synthesis and collagenase secretion
  • Regulates the mitogenic effects of other growth factors
  • Stimulates endothelial chemotaxis and angiogenesis
  • Inhibits macrophage and lymphocyte proliferation

Basic Fibroblast Growth Factor

  • Promotes growth and differentiation of chondrocytes and osteoblasts
  • Mitogenic for mesenchymal stem cells, chondrocytes and osteoblasts

Platelet Derived Growth Factor

  • Mitogenic for mesenchymal stem cells and osteoblasts
  • Stimulates chemotaxis and mitogenesis in fibroblast/glial/smooth muscle cells
  • Regulates collagenase secretion and collagenase synthesis
  • Stimulates macrophage and neutrophil chemotaxis

Epidermal Growth Factor

  • Stimulates endothelial chemotaxis/angiogenesis
  • Regulates collagenase secretion
  • Stimulates epithelial/mesenchymal mitogenesis

Vascular Endothelial Growth Factor

  • Increases angiogenesis and vessel permeability
  • Stimulates mitogenesis for endothelial cells

Connective Tissue Growth Factor

  • Promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion.

Platelet-rich plasma (PRP) carries various growth factors that stimulate cell proliferation and differentiation. Growth factors found in platelet-rich plasma affect the signaling involved in hair follicle development and cycling. PRP therapy represents a new and effective treatment option with minimal associated side effects for those who suffer from alopecia. Blood is drawn from the patient then placed in a centrifuge to separate the red blood cells and the platelet-rich plasma. The injections are generally administered intradermally or subcutaneously in the patients desired sites on the scalp. When PRP is administered, the growth factors in the platelets’ granules bind to the bulge area of the hair follicle leading to the formation of hair epithelium and the differentiation of stem cells in the hair follicles. This stimulates the hair follicles allowing new hair strands to grow.

PRP injections for hair loss treatment offers promising therapeutic effects. PRP injections are autologous therefore there are little to no adverse side effects associated with the treatment.  Due to its regenerative effects and action mechanisms, PRP offers a potential long-term treatment for hair regrowth compared to other conventional medical treatments or therapies.


PRP has many different applications over a wide range of therapeutic areas such as Sports and Orthopedics, Dental, Cosmetic Surgery, Esthetics and Dermatology, General Surgery , Chronic Wounds, Ophthalmology, Veterinary


PRP combined with  ultra-pulsed fractional CO2 laser had a synergistic effect on PRP therapy for facial rejuvination (Hui et al, 2007). Combined application:

  1. Effectively reduces facial wrinkles
  2. Significantly improves skin texture and elasticity
  3. Relieves coarse pores, pigmentation, and erythema caused by laser therapy.

Other clinical studies have demonstrated that PRP induces the proliferation of new fibroblasts within the first few hours. PRP treatment  resulted in notable increased rates of fibroblast migration and also induces the synthesis of collagen fibres that are of higher density and quality.

 PRP can be used to accelerate autologous grafts used for site preparations, sinus lifts, osteointegration, ridge augmentations, etc. An enhanced bone regeneration can be expected when PRP is used with mixtures of autologous bone and bone substitutes and with recombinant human growth factors such as recombinant BMP. PRP has also been shown to increase the quantity and quality of the host bone in areas of localized alveolar defects when used for guided bone regeneration.


Early results are promising that PRP placed in the preparation site of a dental implant will promote and accelerate osteointegration. This may be beneficial in the maxilla, in areas of previous failures, in type IV bone, in osteoporotic women, etc.


Platelet Rich Plasma (PRP) is often used to treat a variety of chronic tendon, acute ligament and muscle injuries as well as other conditions such as arthritis and osteoporosis pain.


Athletes of all competition levels are early adopters of novel treatment methods. They are driven to find less invasive methods of injury management and faster means of returning to their sports.

Ligament, muscle and tendon tears are often slow to heal due to inadequate blood supply to these areas. Although PRP can be injected on any muscle or tendon, the following areas are the most common sites:

  • Shoulder (rotator cuff)
  • Elbow (Lateral or medial Epicondylitis; aka tennis or golfer’s elbow)
  • Knee (patellar tendon; aka Jumper’s knee)
  • Ankle (Achilles Tendon)

PRP can also be used during surgery to augment healing for ACL reconstruction and rotator cuff repair.

Connective tissues such as ligaments and tendons heal by filling in with scar tissue, which in turn, doesn’t support the pressure of large loads effectively and increases the risk of re-injury. Chronic tendon injuries are related to degeneration of the tendon tissue. Traditional forms of therapy do not necessarily improve the tendon’s ability to create new tissue and heal in the same way PRP does.

Platelets release bioactive proteins and growth factors which enhance tissue regeneration and healing. New tendon cells called tenocytes start to develop in the treated area. Cartilage cells called chondrocytes form when PRP is injected into damaged cartilage. There is also an increase in the number of growth factors in the treated area as well as a build-up of Type 1 collagen fibers, which constitute the base structure of tendon tissue. PRP has been demonstrated to shorten recovery time, decrease pain and improve performance in the injured area

  • Many high-profile athletes are also taking advantage of the benefits that PRP offers:
  • Kobe Bryant of the LA Lakers received more than three treatments on his knee in the past few years and was able to make a full comeback after serious injury
  • Alex Rodrigues of the New York Yankees received multiple PRP treatments for both his left shoulder and right knee
  • Peyton Manning (quarterback of the Denver Broncos) had several treatments to help repair ligaments, tissues and alleviate pain in his neck
  • Tiger Woods received PRP treatments for his Achilles tendon and both knees after a knee surgery to repair injury.

(News coverage of PRP usage in athletes)

(Pittsburgh Steelers athletes use PRP as an innovative injury treatment)


Some common orthopedic indications for which PRP is used are listed below:

  • Tendinopathies (refers to a degenerative condition of tendons characterized by the chronic loss of collagen, stability, strength and tissue integrity possibly  caused by natural aging, injury, repetitive stress, and/or neural, vascular and hormonal inputs)
  • Ligament Sprains
  • Muscle Strains
  • Joints (i.e. osteoarthritis; a chronic degenerative disease of hyaline cartilage)

PRP can be effective for many cases of osteoarthritis as repairing the damage has posed a great challenge due to its regenerative limitations. Platelets and other elements within the blood help tendons and ligaments heal by stimulating a repair and growth response that accelerates the process of developing new tissue. However, the tendons and ligaments do not receive a rich blood supply containing these factors which is why they often take a significant amount of time to heal. PRP stimulates healing of cartilage and reduces pain and disability by delivering these factors directly to the site of injury. Areas of treatment can include knee, hip, shoulder and ankle.

With age, the cartilage lining the joints can shrink and wear thin causing friction between the bones. Bone spurs and inflammation can gradually enlarge the joint leading to the pain and dysfunction of arthritis.

Damages to the cartilage have been treated by cortisone and HA injections, micro fracture, debridement and grafting procedures. The results obtained by these techniques are so far unsatisfactory and in most cases, result in the formation of fibrous connective tissue with minimal mechanical strength at the affected area.

Not only does PRP stimulate cellular activity and the process of regeneration and repair, it also improves bone and cartilage recovery, as well as reduce inflammation and pain which could potentially inhibit the deteriorating effects of age and slow the progression of arthritis.

The primary goal of PRP is to resolve pain through healing, therefore, it could prove to have lasting results. Initial improvement may be seen within a few weeks and gradually increase as healing progresses. Research studies and clinical practice have demonstrated PRP injections to be very effective at relieving pain and returning patients to their normal lives.

Ultrasound and MRI imaging have both shown definitive tissue repair after PRP therapy thereby confirming the healing process. The need for surgery can also be greatly reduced by treating injured tissues before the damage progresses to an irreversible condition.


Platelet rich plasma contains the bioactive proteins which act as the catalyst for accelerating the wound healing process. With the increased level of growth factors present in PRP, the tissue maturation phase is accelerated and the overall healing process is significantly improved in terms of post-operative pain, swelling, infection and establishment of tissue texture, colour and contour. PRP’s cohesive nature and its hemostatic properties also allow for minimal bleeding.

Application of PRP yielded adequate hemostasis if PPP was also applied to create a seal to halt bleeding, because PPP contains much higher amounts of fibrinogen.

Growth factors found in PRP permit accelerated tissue regeneration. It can be used to treat corneal lesions and dystrophy, superficial punctuate keratitis, severe dry eye-related ocular surface disorders, ocular GvHD, recurrent erosion syndrome, neurotrophic keratopathy, keratopathy with loss of epithelial-stromal tissue resulting from chemical or physical traumas, sicca syndrome and/or Sjögren’s syndrome.

It also provides nutritional factors necessary to maintain cellular feasibility in the epithelial repair process while reducing the risk of contamination and infection.


Platelet-rich plasma injections have been proven to be an effective and safe alternative treatment for hair loss. Many studies reported positive results when using PRP as a therapy for men and women with alopecia.

Efficacy of PRP for the Treatment of Androgenic Alopecia

Efficacy of PRP for the Treatment of Androgenic Alopecia
(Click here to download full article)

Singhal and colleagues in 2015 investigated the effects PRP has on the hair growth and quality in patients with androgenic alopecia (AA). PRP injections were administered to patients every 2 weeks for four sessions, and the control group who suffered from AA received no treatment. A hair pull test was performed before the initial treatment and then again at every follow-up. Patients were evaluated for hair volume, hair growth, quality and fullness at 1-week intervals. Hair growth was seen in 100 percent of patients. Overall hair quality improved and the number of hairs that came out during the pull test decreased by 65 percent. The control group showed no hair growth improvements. This research supports the use of PRP as an effective and safe treatment option for patients suffering from hair loss.

Platelet-Rich Fibrin Matrix (PRFM) for Androgenetic Alopecia

Platelet-Rich Fibrin Matrix (PRFM) for Androgenetic Alopecia
(Click here to download full article)

In 2014 Scalfani conducted a study to evaluate the effects of platelet-rich fibrin matrix (PRFM) treatments on patients who suffer from androgenetic alopecia. The patients were injected with PRFM intradermally three times a month during the duration of the 1-year study. Follow-ups occurred at one-, two-, three- and six months after the initial treatment. Hair density was measured during each follow-up visit. Overall every patient had an increase in their density. There was an increase in hair densities 2-3 months after the initial treatment with a significant difference in hair densities at approximately 6 months when compared to the baseline measurements. These results indicate that PRFM injections have beneficial therapeutic effects for patients with androgenic alopecia.

Platelet-Rich Plasma in Androgenic Alopecia: Myth or an Effective Tool

Platelet-Rich Plasma in Androgenic Alopecia: Myth or an Effective Tool
(Click here to download full article)

In 2014 Khatu and colleagues studied the safety and clinical efficacy PRP injections have on patients with androgenic alopecia. The patients were treated with PRP injections twice a week for four sessions. During each session a hair pull test was performed, pictures of the scalp were taken, and hair was analyzed for volume, growth, fullness and overall quality. After the treatments there was a significant reduction in hair loss observed the patients. The pull test was negative in 9 out of the 11 patients and there was improvement in hair volume and coverage by the end of the fourth session compared to the first session. PRP injections demonstrate a promising safe and effective treatment option for patients with androgenetic alopecia.


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Please contact your insurance company to see if Revival PRP® is covered by your insurance policy

Tips for Maintaining Healthy Hair

It is normal to lose about 100-150 strands of hair a day, however, some individuals are more prone to hair loss and damage because of the actions they perform on their hair. The Canadian Dermatology Association has ample information regarding tips to maintain healthy hair and prevent further damage, especially for those who are suffering from hair loss.


Why do People Go Bald?

Platelet-rich Plasma for Hair Loss

Natural Remedies for Hair Loss:


There are many societies and associations that aim to support people suffering from hair loss. Click on the links below to learn more about these organizations and how they can help you:

Canadian Hair Loss Foundation:       

Canadian Alopecia Areata Foundation:

Canadian Skin Patient Alliance:         

Canadian Dermatology Association:

To learn more about PRP and its uses in hair growth and restoration, please enter your name and email address below and click submit

By clicking submit, you authorize Xediton Pharmaceuticals to send you information about Revival PRP for hair growth and restoration. You can unsubscribe at any time.


How does REVIVAL PRP® work?
The platelets and growth factors contained in REVIVAL PRP® trigger your body’s natural healing process to regenerate damaged tissues. Hair loss results from hair follicles gradually shrinking, which produces thinner and thinner hairs until, eventually, they stop producing hair altogether. Injecting platelet-rich plasma into the dermis of the scalp can stimulate these shrinking hair follicles to become healthier and larger, reversing the thinning process and facilitating fuller, thicker hair growth.
How is the procedure done?
The procedure is very simple and fast. A small amount (11 to 20 ml, or two to four tablespoons) of your blood is drawn and centrifuged, which separates the blood liquid fraction or plasma and the platelets from other cellular components. The scalp is prepared with an antiseptic solution and anesthetic to completely numb the scalp for a relatively painless procedure. Small injections of the activated PRP deliver the powerful platelet-derived growth factors into the skin at the level of the weak follicles, all in less than 30 minutes.
Does it hurt?
The process is intended to cause minimal discomfort. Since plasma is re-injected into the scalp. In some cases, there may be some sensitivity to the injection site that does not last very long. The practitioner may use topical analgesics to help reduce the potential discomfort in those cases.
What can I expect after the procedure?
Most patients notice a brief period of inflammation during which their scalp remains somewhat pink and numb for a few hours. Swelling is rare (about 15% of the time) and if it occurs, it is noticeable around the forehead or around the eye area the next day. Any swelling takes about a day or two to resolve.
How many sessions are required?
PRP therapy can be repeated every 1-2 months and usually 3-4 sittings are sufficient, though some patients may require maintenance therapy once a year or more frequently depending upon the severity of hair loss. The visible results in the form of new hair growth can be seen after 3-4 months of treatment and further improvement is noticed in the subsequent months.
Is the treatment time consuming?
No. Session duration will depend on what conditions are being treated, however, the procedure normally takes about 45-60 minutes.
What is the recovery time?
There is no activity restriction after a PRP treatment. Patients may shower/shampoo/condition their hair normally just several hours after the treatment and resume normal daily and athletic activities. As mentioned previously, some brief mild inflammation noticeable as redness/pinkness and numbness of the scalp may be present for several hours. No harsh chemical coloring or perming treatments should be performed for at least 72 hours. Depending on the area treated and your skin profile, your practitioner might suggest some additional care instructions and precautions.
How long will it take before I see results?
Depending on the extent of the damage, hair growth improvements can typically be measured in about three months, but it takes six to twelve months to visually “see” the difference in photos and in the mirror.
How long do the results last?
According to published reports, “plain” PRP (without ECM) tends to improve hair caliber and hair growth for about four to six weeks, requiring multiple repeated treatments as often as every other month. On average, however, most patients will require their repeat PRP treatment after an average of one year in order to maintain the hair growth effects. Except for alopecia areata, the average hereditary hair loss patient can expect to need PRP on an annual basis.
What causes hair loss in men and women?
In men, hair loss follows a very specific, progressive pattern that is passed on through heredity and is triggered by the hormone–specifically dihydrotestosterone or DHT. As hair follicles miniaturize and weaken, coverage of the scalp diminishes leaving thinning or balding areas. Hair thinning in women is mainly due to genetics and can start any time after puberty. However, female pattern hair loss can be strongly influenced by age, nutrition, stress, surgery, medications, illness, social/lifestyle factors, hair care and more. As hair follicles weaken and stop producing hair, hair loss occurs.
Who is the ideal candidate for PRP treatment?
There are two types of hair loss patients when it comes to PRP treatments: patients with areas of “weak quality” hair growth on the scalp, where functioning hair follicles can still be observed, and patients with small areas of alopecia areata. These types of patients usually have the greatest success with PRP hair regrowth treatments.
Patients should always be evaluated by a healthcare professional to ensure that they are in good overall health and can receive PRP therapy.
Will PRP work on an area that is balding?
PRP works best on areas where there is existing hair that is thinning.
Are there any contraindications or other factors that would make someone ineligible for PRP?
Patients should be educated by their Hair Restoration Physician as to what results they could expect from PRP in various areas of the scalp. Different areas of the scalp may respond differently to PRP depending on the number of weak hair follicles present in each zone. Generally, except for small round areas of alopecia areata, locations, where severe depletion of follicles has occurred, should not be treated. Most healthy individuals can easily undergo PRP treatments. Certain conditions like blood and platelet disorders, chronic liver disease, presence of an active severe infection, cardiovascular or hemodynamic instability and/or the presence of anticoagulation therapy (e.g. warfarin) would make PRP contraindicated. Recent steroid treatments and smoking are relative contraindications and should be discussed with your Hair Restoration Physician.
Can I use REVIVAL PRP® to treat my hair loss caused by chemotherapy?
Hair loss due to chemotherapy is an extremely stressful side effect of an already apprehensive procedure. While PRP can be used after chemo is completed, it is not recommended while chemo treatment continues. This prevents one treatment from affecting the other and helps you get better results.
Can PRP be combined with a hair transplant?
Yes, PRP can be combined before, during or after the transplant procedure. It not only helps the transplanted hair regrow faster, but it also stimulates existing thinning hair at the same time
How much does PRP for hair loss cost?
The cost to have PRP treatment done for hair loss varies from doctor to doctor. Remember, multiple sessions may be needed for this to be effective. Be sure to contact your doctor to inquire about how much their PRP therapy costs as it changes based on location and clinic.
Will my insurance cover REVIVAL PRP®?
Please consult your insurance company to verify coverage. Every company has different guidelines for reimbursement, but generally, PRP procedures are not reimbursed. This means that some or all the costs associated with the procedure may need to be covered by the patient at the time of treatment.
How is a hair loss diagnosis obtained?
The first step for anyone with a hair or scalp problem is to visit a full-time, credentialed hair restoration physician with experience and expertise in accurate diagnosis, successful treatment and long-term follow-up required in the medical management of hair loss patients. A medical hair loss “work up” starts with a detailed medical history, including family history, history of medical illness, poor nutrition, current medications, hair care regimen, recent surgeries and a detailed history of the hair loss situation.
A scalp biopsy, blood work or other testing may be performed if indicated by the history and physical symptoms. A physical exam would include evaluation of the scalp for signs and symptoms of hair loss and any concurrent problems, such as inflammation.
Should inflammation be a major concern in the use of PRP therapy?

No, REVIVAL PRP® is formulated with an Advanced Separator Gel that acts as a physical separation barrier which traps cells that induce inflammation such as the granulocytes below the separator gel. This results in accessible plasma which is rich in platelets and growth factors but almost completely depleted of non-desirable inflammatory cells.

Clinicians do not want red or white cells that cause bruising and inflammation which delays the healing process of the skin. For this reason, the REVIVAL PRP® separator system is ideal for esthetic procedures.

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