SIZE: Box of 90 (3 x 30 blister-packed) tablets
INDICATIONS: Anandron® (nilutamide) is indicated in the treatment of metastatic prostatic carcinoma (Stage D2) in conjunction with surgical castration.
DIRECTIONS: Initial dosage: 300 mg once daily for the first month of treatment. Maintenance dosage: 150 mg once daily, may be started earlier should intolerance occur.
INDICATIONS AND CLINICAL USE
Anandron® (nilutamide) is indicated in the treatment of metastatic prostatic carcinoma (Stage D2) in conjunction with surgical castration.
This medication is typically used only once a day. However, your doctor or pharmacist may have suggested a different schedule that is more appropriate for you. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed.
It must be used regularly and continuously to maintain its beneficial effects. Be sure to keep an adequate supply on hand. This medication may be taken with or without food.
If you drink alcohol, moderate consumption is recommended. Talk to your pharmacist or doctor to find out exactly how much alcohol you can drink.
Anandron® (nilutamide is contraindicated in:
− patients with known hypersensitivity to the drug, or to any constituents of the drug product
− patients with severe hepatic dysfunction
− patients with severe respiratory insufficiency
− women and children.
The hepatic and respiratory state of the patient should be evaluated and the necessity to report any respiratory symptoms as soon as they appear should be emphasized. Cases of interstitial lung disease such as pneumonitis and pulmonary fibrosis have been reported with the use of Anandron® (nilutamide). Some cases of pulmonary fibrosis were fatal. Baseline imaging (eg. chest X-ray) should be performed prior to therapy. Baseline pulmonary function tests may be considered. In the event of dyspnea or worsening of pre-existing dyspnea, treatment with Anandron® should be discontinued and appropriate medical treatment should be initiated. If interstitial lung disease is diagnosed, Anandron® must be discontinued to reduce the risk of progression to pulmonary fibrosis; corticosteroid treatment may be considered. Cases of hepatic dysfunction have been reported with the use of Anandron®. If clinical symptoms give rise to a suspicion of liver dysfunction, transaminases should be measured. If an increase in serum transaminases above three times the upper limit of normal laboratory range is shown, treatment must be interrupted.
The most common side-effects affect the eyes. The patient may notice that your eyes require more time to adapt to darkness, especially when there is a sudden change in lighting (for example, driving through a tunnel). When it occurs, this problem is almost always temporary and may be improved by wearing tinted glasses. However, until the patient’s eyes accommodate better to the dark, the patient should be very careful when driving or operating machinery. Some patients may develop breathing problems or a worsening of a pre-existing breathing problem. Symptoms may include shortness of breath, coughing, chest pain and fever. Fatal cases due to pulmonary problems have been reported during Anandron® treatment. It is important that the patient contacts you immediately if they have any breathing difficulties while taking Anandron®. In rare cases, Anandron® may cause an increase in liver tests and, very rarely, hepatitis. Symptoms that may suggest a liver problem include: persistent lack of appetite, nausea (queasiness), vomiting, abdominal pain or tenderness, jaundice (yellow eyes and/or skin), dark urine, itching or unexplained flu-like symptoms.
ABOUT THE DISEASE
The goals of treatment are to:
- Manage symptoms
- Slow the rate your cancer grows
- Shrink the tumor
Some cancers are called “locally advanced.” That means the cancer has spread from the prostate to nearby tissue. It’s not the same as metastatic cancer since it hasn’t spread to other parts of your body. Many locally advanced prostate cancers can be cured.
How Prostate Cancer Spreads
Cancer cells sometimes break away from the original tumor and go to a blood or lymph vessel. Once there, they move through your body. The cells stop in capillaries — tiny blood vessels — at some distant location.
The cells then break through the wall of the blood vessel and attach to whatever tissue they find. They multiply and grow new blood vessels to bring nutrients to the new tumor. Prostate cancer prefers to grow in specific areas, such as lymph nodes or in the ribs, pelvic bones, and spine.
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FREQUENTLY ASKED QUESTIONS
Anandron® is a medicine for treating prostate cancer in men. It contains the active ingredient nilutamide. Anandron® belongs to a family of medicines called non-steroidal anti-androgens. These medicines work by blocking the effect of androgen hormones that are naturally produced by your body. Prostate cancer cells are dependent on these hormones, and blocking their effect is intended to stop the growth of the cancer.
Anandron® is more effective when used at the same time as other medicines known generally as luteinizing hormone-releasing hormone (LHRH) agonists or, alternatively, following surgery designed to treat prostate cancer. Your doctor may have prescribed Anandron® for another reason. Ask your doctor if you have any questions about why Anandron® has been prescribed for you.
Anandron® is available only with a doctor’s prescription. Before using them, discuss any other drugs you may be taking or if you intend to use complementary medicines. It is difficult to predict how long Anandron will be effective for any given individual.
Therefore, if it is almost time for your next dose when you remember that you have missed a dose, skip the dose you missed and take your next dose at the usual time (i.e. do not take a double dose). If you are concerned or if you have missed more than one dose, please speak to your doctor
If you take, by mistake, too many tablets on the same day, you may feel nauseous and dizzy, and you may vomit. These symptoms will normally go away after temporarily interrupting your treatment or reducing the dose, however these steps should only be taken on your doctor’s advice. If you have taken more than 300 mg in one day, you should contact your doctor as soon as possible.